The University of Minnesota is an equal opportunity educator and employer, Office of the Vice President for Research | Contact U of M | Privacy Policy, Mary Van Beusekom | News Writer | CIDRAP News, Two recent papers claim there are no differences between surgical masks and respirators for preventing the spread of respiratory diseases like COVID-19 and flu, but the articles. * https://covid.cdc.gov/covid-data-tracker/#variant-proportions, https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covid-net/purpose-methods.html. Sadoff, J. et al. PubMed Effectiveness of BNT162b2 Vaccine against Omicron Variant in South N. Engl. https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1, https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb. You are using a browser version with limited support for CSS. Iowa does not provide data on vaccination status. Cohen-Stavi, C. J. et al. CDC twenty four seven. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Classification of omicron (B.1.1.529): SARS-CoV-2 variant of concern. Adults with a positive result whose SARS-CoV-2 test date was 14 days after the first dose of a 2-dose series but <14 days after receipt of the second dose were considered partially vaccinated. To obtain N. Engl. Clinical trends among U.S. adults hospitalized with COVID-19, March to December 2020: a cross-sectional study. There was no link between risk of COVID-19 death and race, except for Indian patients, who were at slightly higher risk than their White peers. How the Omicron Surge Is Taxing Hospitals - Healthline J. Med. Vaccine effectiveness for 1 dose during the first 6 months of life was 68% (95% CI: 12, 88) (Table2). Experts say they. Hospitalization rates during peak Omicron circulation (January 2022) among unvaccinated adults remained 12 times the rates among vaccinated adults who received booster or additional doses and four times the rates among adults who received a primary series, but no booster or additional dose. NEW YORK and MAINZ, GERMANY, March 1, 2023 Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today submitted an application to the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) of a booster (fourth) dose of the companies' Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine in children 6 months through 4 years of age (also referred to as under 5 years). JAMA 326, 16291631 (2021). IMV status was missing in 1.4% (weighted) of hospitalizations; these hospitalizations are otherwise included elsewhere in the analysis. All adjustment variables were selected a priori based on prior work36. 386, 15321546 (2022). Omicron up to 70% less likely to need hospital care - BBC News Finally, the COVID-NET catchment areas include approximately 10% of the U.S. population; thus, these findings might not be nationally generalizable. Health and Human Services. Nursing home residents have been disproportionately affected by COVID-19; older age, comorbidities, and the congregate nature of nursing homes place residents at higher risk for infection and severe COVID-19-associated outcomes . By clicking Sign up, you agree to receive marketing emails from Insider SARS-CoV-2 infection can lead to severe illnesses and hospitalizations in children and infants2,3,4,5. Nature Communications (Nat Commun) To update your cookie settings, please visit the, https://doi.org/10.1016/S0140-6736(22)00462-7, Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study, https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern, https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/scientific-brief-omicron-variant.html, https://www.mrc-bsu.cam.ac.uk/now-casting/report-on-nowcasting-and-forecasting-9th-december-2021/, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1050999/Technical-Briefing-35-28January2022.pdf, https://www.research.ed.ac.uk/en/publications/severity-of-omicron-variant-of-concern-and-vaccine-effectiveness-, https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-50-severity-omicron/, https://doi.org/10.1101/2022.01.11.22269045, https://doi.org/10.1101/2022.01.12.22269179, https://doi.org/10.1101/2022.01.20.22269406, https://doi.org/10.1101/2022.01.12.22269148, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1054071/vaccine-surveillance-report-week-6.pdf, https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-routine-variant-data-update, https://www.gov.uk/government/publications/nhs-test-and-trace-statistics-england-methodology/nhs-test-and-trace-statistics-england-methodology, https://www.england.nhs.uk/contact-us/privacy-notice/national-flu-vaccination-programme/, https://digital.nhs.uk/data-and-information/data-collections-and-data-sets/data-sets/emergency-care-data-set-ecds, https://digital.nhs.uk/services/secondary-uses-service-sus, https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-hospital-activity/, https://doi.org/10.1101/2021.08.13.21262014, View Large All adults should stay up to date (1) with COVID-19 vaccination to reduce their risk for COVID-19associated hospitalization. These findings are consistent with the diminishing of pregnancy-derived antibodies in infants over time22. Vaccination status (unvaccinated, receipt of a primary series only, or receipt of a primary series plus a booster or additional dose) was determined for individual hospitalized patients and for the catchment population using state immunization information systems data (2). Ferdinands, J. M. et al. Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of In conclusion, in this population-based cohort study, we found that infants born to mothers who received at least two doses of an mRNA COVID-19 vaccine during pregnancy were at lower risk of testing positive for SARS-CoV-2 and were at lower risk of hospitalization during the first 6 months of life compared with infants whose mothers were unvaccinated during pregnancy. During the Omicron-predominant period, hospitalization rates increased among unvaccinated persons and those who completed a primary series, with and without receipt of a booster or additional dose (Figure 2). Google Scholar. Further information on research design is available in theNature Portfolio Reporting Summary linked to this article. Includes current treatment or recent diagnosis of an immunosuppressive condition or use of an immunosuppressive therapy during the preceding 12 months. Persons who received no doses of any COVID-19 vaccine were considered unvaccinated. Centers for Disease Control and Prevention. *** An additional 172 (3.4%, 95% CI = 2.7%4.2%) adults were partially vaccinated, 69 (0.9%, 95% CI=0.61.2) received a primary vaccination series <14 days before receiving a positive SARS-CoV-2 test result, and 186 (4.1%) had unknown vaccination status; these groups are not further described in this analysis. However, a milder virus could still put pressure . New charts from the Centers for Disease Control and Prevention (CDC), more severe disease and more hospitalizations, Insider's Catherine Schuster Bruce reported. Stay up to date with what you want to know. Relative to the Delta-predominant period, a larger proportion of hospitalized Black adults were unvaccinated. Includes current treatment or recent diagnosis within the previous 12 months of an immunosuppressive condition or use of an immunosuppressive therapy. A study from the U.K. government, published last week, found that three doses of vaccine. Dr. Klein reported receiving grants from Pfizer, Merck, GlaxoSmithKline, and Sanofi Pasteur. TN, NMF, SB, EV, SRS, DDA, and AMP developed the methodology. https://downloads.aap.org/AAP/PDF/AAP%20and%20CHA%20-%20Children%20and%20COVID-19%20State%20Data%20Report%209.29.22%20FINAL.pdf?_ga=2.255000394.335550773.1665001859-370326403.1636740765 (2022). Omicron Is Not More Severe for Children, Despite Rising Hospitalizations More children are being treated for Covid, but a combination of factors, including low vaccination rates, most. Article The second study, led by Office for National Statistics researchers in Wales, involved death rates and risk factors in adults in England who had received an mRNA booster at least 14 days before Dec 31, 2021. Despite several studies showing that vaccination during pregnancy is safe for pregnant people24,25,26,27,28, vaccine uptake has been suboptimal in this group29. Open 5, e2233273 (2022). Effectiveness of BNT162b2 vaccination during pregnancy in preventing hospitalization for SARS-CoV-2 in infants. J. Med. Immunogenicity and Reactogenicity of the Beta-variant Recombinant This can lead to overestimates of first doses and underestimates of subsequent doses, and underestimates of hospitalization rates in persons who received additional or booster doses. Late last year, as Omicron was spreading fast in the US, hospitalization rates per 100,000 rose sharply among unvaccinated adults, while rates in those who were fully vaccinated remained. Maternal vaccination with at least two doses reduced the infants risk of testing SARS-CoV-2 positive initially by 84% which decreased to 56% by 6 months of life in the Delta dominant period. MB), Help with 1). However, infants aged <6 months are not currently eligible for any currently available COVID-19 vaccines and must rely on placentally acquired immunity from their mothers. of Omicron-infected patients with a high rate of vaccination in China. Infect. Slider with three articles shown per slide. Views equals page views plus PDF downloads. We, therefore, were unable to assess whether maternal infection provided some protection to their infants. By submitting a comment you agree to abide by our Terms and Community Guidelines. While Omicron caused a big spike in COVID-19 cases, vaccinated people continued to be less likely to be hospitalized than the unvaccinated. Google Scholar. J. Epidemiol. Razzaghi, H. et al. Pregnant women were excluded because their reasons for hospital admission (4) might differ from those for nonpregnant persons. Am. The KPNC Institutional review board approved and waived consent for this study. Initial hospital data from England and Denmark also suggest Omicron cases are less severe. Association of COVID-19 vaccination during pregnancy with incidence of SARS-CoV-2 infection in infants. Wkly. Thank you for visiting nature.com. The vaccines have proved highly safe and effective at reducing the risk of severe illness, hospitalization and death. Receipt of one dose especially during the third trimester was also associated with a reduced risk of infants testing positive for SARS-CoV-2 during the first 6 months of life during the Delta dominant period. However, protection estimates greater than 90% might be too high if individuals with a previous infection were more likely than those without one to come forward for a test for reasons other than suspicion of COVID-19. Vaccine 40, 656665 (2022). Although both approaches adjusted for the same confounding factors, the effectiveness estimates from the TND were higher than those from the cohort design, which is consistent with our previous analyses of influenza vaccine effectiveness in which we also observed that the TND tended to result in higher vaccine effectiveness estimates than did our cohort analyses30. 552a; 44 U.S.C. But the average . Informed consent was waived because this was a data-only study with no direct contact with participants. Provided by the Springer Nature SharedIt content-sharing initiative. This conversion might result in character translation or format errors in the HTML version. Weekly / March 25, 2022 / 71(12);466473. The research was published yesterday in JAMA Internal Medicine. If SARS-CoV-2 test date was missing, hospitalization admission date was used. All information these cookies collect is aggregated and therefore anonymous. Department of Health and Human Services. Among nonpregnant and pregnant adults aged 18 years, hospitalization rates were calculated overall, and by race/ethnicity and COVID-19 vaccination status. We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. We also conducted analyses based on the trimester during which the vaccine was received during pregnancy (first, second, or third trimester). Relative to the Delta-predominant period, the proportion of cases in non-Hispanic Asian or Pacific Islanders also increased, whereas the proportion in all other racial and ethnic groups decreased. Sarah J. N. Engl. Egyptian hemodialysis patients' willingness to receive the COVID-19 During the proxy omicron period, we found a vaccine effectiveness of 70% (95% confidence interval . Viruses | Free Full-Text | SARS-CoV-2 Seroprevalence among Canadian Vaccinated patients were older (68 vs. 57 years), and 62% had at least one comorbidity Admission to the ICU was 20%, and the mortality rate at 30 days was 14%. Lipkind, H. S. et al. BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting. According to the Ontario Science Table's online dashboard, the hospital occupancy rate for the unvaccinated was 611 per million unvaccinated people in the province's population as of Jan. 7,. No other exclusion criteria were applied. J. Pediatr. Unvaccinated Children Hospitalized at Twice the Rate During Omicron In this large study which included >30,000 infants, we found that receipt of at least two doses of mRNA COVID-19 vaccine during pregnancy was associated with a decreased risk of infants testing SARS-CoV-2 positive during their first 6 months of life. Using previously described methods (3), investigators collected clinical data on a representative sample of adult patients (7.9%) hospitalized during July 1, 2021January 31, 2022, stratified by age and COVID-NET site. COVID-NET conducts population-based surveillance for laboratory-confirmed COVID-19associated hospitalizations in 99 counties across 14 states. COVID-19associated hospitalizations are those occurring among residents of a predefined surveillance catchment area who have a positive real-time reverse transcriptionpolymerase chain reaction (RT-PCR) or rapid antigen detection test result for SARS-CoV-2 during hospitalization or the 14 days preceding admission. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: 21,48), 14% (CI: 9,32) and 13% (CI: 3,26), respectively. Omicron and the vaccines: Your questions answered | AAMC GD declares that his employer UK Health Security Agency (previously operating as Public Health England) received funding from GlaxoSmithKline for a research project related to influenza antiviral treatment. However, these Omicron impacts have been mostly observed in countries with high vaccination rates in the Region: the comparatively lower rate of hospitalizations and deaths so far is in large part thanks to vaccination, particularly of vulnerable groups. During the Delta period, receipt of one dose during the third trimester reduced infants risk of testing positive for SARS-CoV-2 by 74% (95% CI: 19, 92) during the first 6 months of life (Table3). Vaccines and Omicron mean Covid now less deadly than flu in England Rep. 71, 429436 (2022). RESP-NET: COVID-19 Associated Hospitalization Rates among Adults Ages 65 Years and Older CDC's Respiratory Virus Hospitalization Surveillance Network (RESP-NET) shows that overall weekly rates of COVID-19-associated hospitalizations have declined for all age groups from a peak in December 2022. Data about boosters was only available for those over 50. We further classified vaccination status by the trimester within which the second dose or the unique dose (for those who received only one dose) was received. Late last year, as Omicron was spreading fast in the US, hospitalization rates per 100,000 rose sharply among unvaccinated adults, while rates in those who were fully vaccinated remained low. On the bias of estimates of influenza vaccine effectiveness from test-negative studies. NMF, SB, SFunk, ACG, DDA, and AMP acquired funding. The Lancet Regional Health Southeast Asia, The Lancet Regional Health Western Pacific, 36-fold higher estimate of deaths attributable to red meat intake in GBD 2019: is this reliable? The company also said full results of its 2,250-person study confirmed the pill's promising early results against the virus: The drug reduced combined hospitalizations and deaths by about 89. Stay up to date with your COVID-19 vaccines. Second, vaccination status is subject to misclassification; this might affect estimation of rates by vaccination status. In the first study, a team led by US Centers for Disease Control and Prevention (CDC) researchers analyzed data on 192,509 hospitalizations from more than 250 hospitals in 13 states participating in the COVID-19Associated Hospitalization Surveillance Network from Jan 1, 2021, to Apr 30, 2022. As a result, the number of total hospitalizations exceeds the sum of unvaccinated adults, adults who received a primary series without a booster or additional dose, and adults who received a primary series with a booster or additional dose. 3501 et seq. All adults should stay up to date (1) with COVID-19 vaccination to reduce their risk for COVID-19associated hospitalization. Morb. This was the highest age-adjusted weekly rate observed among any racial and ethnic group during the pandemic. While this proportion might not be representative of the proportion of vaccinated pregnant women within KPNC because of our exclusion criteria, more efforts are needed to promote COVID-19 vaccines for pregnant persons because vaccination provides protection to mothers and their infants until they are old enough to receive their own COVID-19 vaccines. Relative to the Delta-predominant period, a significantly shorter median length of hospital stay was observed during the Omicron-predominant period and smaller proportions of hospitalizations with intensive care unit admission, receipt of invasive mechanical ventilation, or in-hospital death. Accessed March 10, 2022. To ensure stability and reliability of rates by vaccination status, data are presented beginning 14 days after at least 5% of the age group-specific population of the COVID-NET surveillance catchment area has received an additional or booster dose. In the present study, the mothers of only 32% of infants in the cohort received at least 2 doses during pregnancy.